DMRT2

Across TCGA cell cohorts, DMRT2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DMRT2-associated genes across cancer lineages are ZPBP2, OR10G2, and RNASE8. Each is linked with DMRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRT2-to-partner and partner-to-DMRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPBP2 grouped by DMRT2-low versus DMRT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT2→partner) and Y-score (partner→DMRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZPBP2 →	+0.502	+3.847	<.001	.004	3	2
BLOOD_Leukemia	OR10G2 →	+1.050	+3.966	<.001	.001	3	2
LARGE_INTESTINE	RNASE8 →	+0.042	+3.345	<.001	.007	3	2
BLOOD_Leukemia	WNT3A →	+0.052	+4.169	<.001	.003	3	1
BLOOD_Leukemia	SPATA19 →	+0.015	+4.569	<.001	.003	3	1
BLOOD_Leukemia	WFDC12 →	+0.160	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ZPBP2 by DMRT2 expression — BLOOD_Leukemia

Explore this box plot interactively →