DMRT2

Across TCGA pan-cancer cohorts, DMRT2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DMRT2 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DMRT2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DMRT2 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUSC show a favorable association.

UVM, BLCA, and ACC are the cancer types where DMRT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.753	0.448	<.001	107	view →
BLCA	OS	Tertile	All	0.283	0.477	<.001	86	view →
ACC	OS	Quartile	All	0.671	0.940	<.001	78	view →
KIRP	DFS	Quartile	III,IV	0.100	0.652	<.001	71	view →
KIRC	DFS	Median	IV	0.386	0.600	.002	70	view →
LUSC	OS	Median	All	0.805	0.714	<.001	44	view →
LGG	OS	Tertile	All	0.705	0.866	<.001	35	view →
CESC	OS	Median	All	0.927	0.815	.001	30	view →
LIHC	DFS	Tertile	All	0.371	0.575	.010	21	view →
STAD	DFS	Median	III,IV	0.261	0.566	.011	14	view →
BRCA	OS	Tertile	III,IV	0.911	0.794	.009	13	view →
HNSC	OS	Tertile	All	0.254	0.553	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DMRT2–UVM (OS)

Open the UVM breakdown →