DMPK

Across TCGA cell cohorts, DMPK mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DMPK-associated genes across cancer lineages are BMP5, MYMK, and FOXR2. Each is linked with DMPK in more than 1 cancer types. Because this analysis shows association rather than direction, both DMPK-to-partner and partner-to-DMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP5 grouped by DMPK-low versus DMPK-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMPK→partner) and Y-score (partner→DMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BMP5 →	+0.268	+3.906	.003	.001	3	2
SKIN	MYMK →	+0.038	+3.700	<.001	.009	3	2
SKIN	FOXR2 →	+1.601	+3.706	<.001	.002	3	2
BLOOD_Leukemia	OR1Q1 →	+0.351	+3.714	<.001	.005	3	2
BLOOD_Leukemia	OR1L3 →	+0.101	+5.013	<.001	<.001	3	2
BLOOD_Myeloma	OR6X1 →	+0.020	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

BMP5 by DMPK expression — SKIN

Explore this box plot interactively →