DMP1

Across TCGA patient cohorts, DMP1 mutation is significantly associated with the RNA expression of many other genes, with 1,614 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMP1-associated genes across cancer lineages are MIR5787, MAST4-IT1, and MIR8063. Each is linked with DMP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DMP1-to-partner and partner-to-DMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5787 grouped by DMP1-low versus DMP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMP1→partner) and Y-score (partner→DMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5787 →	+0.324	+4.733	<.001	.004	3	3
STAD	MAST4-IT1 →	+0.244	+3.827	<.001	.005	3	3
READ	MIR8063 →	+0.395	+5.257	<.001	.002	3	2
HNSC	RN7SKP211 →	+0.099	+4.526	<.001	.007	3	2
UCEC	EN2 →	+1.035	+2.592	.007	.006	3	2
UCEC	VDAC1P1 →	+0.433	+2.617	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,614 associations by consensus.

MIR5787 by DMP1 expression — LUSC

Explore this box plot interactively →