DMP1

Across TCGA cell cohorts, DMP1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMP1-associated genes across cancer lineages are AADACL3, MGAT4D, and TSPY3. Each is linked with DMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMP1-to-partner and partner-to-DMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AADACL3 grouped by DMP1-low versus DMP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMP1→partner) and Y-score (partner→DMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AADACL3 →	+0.015	+4.169	<.001	.002	3	1
SOFT_TISSUE	MGAT4D →	+0.004	+4.392	<.001	.004	3	1
SOFT_TISSUE	TSPY3 →	+0.040	+4.392	<.001	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.192	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ECE2 →	+0.332	+4.054	<.001	.004	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

AADACL3 by DMP1 expression — SOFT_TISSUE

Explore this box plot interactively →