DMGDH

Across TCGA patient cohorts, DMGDH mutation is significantly associated with the RNA expression of many other genes, with 4,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMGDH-associated genes across cancer lineages are ZFAND2B, MED8, and ATG4B. Each is linked with DMGDH in more than 2 cancer types. Because this analysis shows association rather than direction, both DMGDH-to-partner and partner-to-DMGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFAND2B grouped by DMGDH-low versus DMGDH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMGDH→partner) and Y-score (partner→DMGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZFAND2B →	+0.315	+2.577	<.001	<.001	3	3
UCEC	MED8 →	+0.289	+1.789	.002	.008	3	3
UCEC	ATG4B →	+0.346	+1.970	<.001	<.001	3	3
UCEC	REEP4 →	+0.670	+4.818	<.001	<.001	3	3
UCEC	HRAS →	+0.508	+3.115	<.001	<.001	3	3
UCEC	COX8A →	+0.327	+2.543	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,555 associations by consensus.

ZFAND2B by DMGDH expression — SKCM

Explore this box plot interactively →