Across TCGA patient cohorts, DMD protein abundance is significantly associated with the RNA expression of many other genes, with 14,334 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DMD-associated genes across cancer lineages are SCN7A, SRPX, and SGCA. Each is linked with DMD in more than 9 cancer types. Because this analysis shows association rather than direction, both DMD-to-partner and partner-to-DMD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMD→partner) and Y-score (partner→DMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SCN7A →	+1.541	+0.400	<.001	<.001	3	10
GBM	SRPX →	+1.402	+0.401	<.001	.007	3	9
HNSC	SGCA →	+1.548	+1.420	<.001	<.001	3	9
HNSC	CASQ2 →	+2.846	+1.326	<.001	<.001	3	9
OV	AOC3 →	+1.534	+0.439	<.001	.001	3	9
HNSC	ABCA8 →	+1.438	+1.560	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,334 associations by consensus.

Exploration

DMD survival (RNA) · tumor vs normal (RNA) · all DMD data types