Across TCGA patient cohorts, DMD mutation is significantly associated with the total protein of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMD-associated genes across cancer lineages are Caveolin-1, eIF4E, and Caspase-7-cleavedD198. Each is linked with DMD in more than 6 cancer types. Because this analysis shows association rather than direction, both DMD-to-partner and partner-to-DMD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMD→partner) and Y-score (partner→DMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Caveolin-1 →	-0.472	-1.321	.042	.032	3	7
UCEC	eIF4E →	+0.135	+1.137	.002	<.001	3	5
STAD	Caspase-7-cleavedD198 →	+0.576	+1.874	.003	.001	3	5
STAD	4E-BP1 →	+0.291	+1.716	<.001	.002	3	5
STAD	Cyclin-E2 →	+0.084	+1.021	.018	.024	3	5
COAD	INPP4B →	-0.407	-2.137	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

Exploration

DMD survival (RNA) · tumor vs normal (RNA) · all DMD data types