DMD

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, DMD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DMD-associated GO terms across cancer lineages are Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion, Regulation of skeletal muscle contraction, and Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Each is linked with DMD in more than 18 cancer types. Because this analysis shows association rather than direction, both DMD-to-partner and partner-to-DMD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DMD→partner) and Y-score (partner→DMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_SCLCRegulation of skeletal muscle contraction by regulation of release of sequestered calcium ion →-0.242-2.078<.001<.001319
LIVERRegulation of skeletal muscle contraction →-0.245-2.377<.001<.001313
BLOOD_MyelomaRegulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum →-0.158-1.883.003.001213
LIVERRegulation of skeletal muscle contraction by calcium ion signaling →-0.270-2.216<.001<.001212
OVARYTelomere maintenance via telomerase →+0.070+0.951.002.00338
BLOOD_MyelomaRegulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion →-0.184-1.721<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Exploration