Across TCGA cell cohorts, DMD mutation is significantly associated with the RNA expression of many other genes, with 1,334 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMD-associated genes across cancer lineages are NUP54, LIM2, and MED11. Each is linked with DMD in more than 3 cancer types. Because this analysis shows association rather than direction, both DMD-to-partner and partner-to-DMD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMD→partner) and Y-score (partner→DMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP54 →	+0.427	+2.222	<.001	.001	3	4
SOFT_TISSUE	LIM2 →	+1.481	+4.930	<.001	.008	3	3
SKIN	MED11 →	+0.473	+3.169	.005	.005	3	3
SKIN	STK32C →	+0.625	+3.169	.006	.009	3	3
LARGE_INTESTINE	CCNB3 →	+0.431	+1.483	.003	.002	3	3
LARGE_INTESTINE	NAE1 →	+0.496	+1.584	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,334 associations by consensus.

Exploration

DMD survival (RNA) · tumor vs normal (RNA) · all DMD data types