DMC1

Across TCGA patient cohorts, DMC1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMC1-associated genes across cancer lineages are ATM, eEF2, and EGFR_pY1068. Each is linked with DMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMC1-to-partner and partner-to-DMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DMC1-low versus DMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMC1→partner) and Y-score (partner→DMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.489	-3.156	.011	.018	3	2
UCEC	eEF2 →	+0.397	+1.700	.008	.044	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.906	.008	.001	3	1
UCEC	G6PD →	+0.422	+1.700	.002	.044	3	1
UCEC	mTOR_pS2448 →	-0.148	-3.156	.019	.018	3	1
UCEC	p62 Lck ligand →	+0.394	+2.179	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by DMC1 expression — UCEC

Explore this box plot interactively →