DMC1

Across TCGA pan-cancer cohorts, DMC1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DMC1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher DMC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DMC1 expression acts as an unfavorable survival marker, although some lineages such as OV and UCS show a favorable association.

KICH, ACC, and OV are the cancer types where DMC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.502	1.000	.001	91	view →
ACC	OS	Median	II,III,IV	0.752	0.942	<.001	62	view →
OV	OS	Quartile	III,IV	0.436	0.290	.002	62	view →
UCS	DFS	Median	IV	0.909	0.416	.008	54	view →
LGG	DFS	Median	All	0.649	0.819	<.001	43	view →
SKCM	OS	Tertile	III,IV	0.920	0.734	.001	43	view →
UVM	DFS	Tertile	II,III,IV	0.269	0.730	.006	38	view →
KIRP	DFS	Quartile	III,IV	0.774	0.135	.010	16	view →
PAAD	DFS	Quartile	All	0.209	0.443	.007	15	view →
LUAD	OS	Median	III,IV	0.721	0.576	.029	13	view →
BLCA	OS	Median	IV	0.549	0.243	.012	12	view →
UCEC	OS	Median	III,IV	0.711	0.482	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DMC1–KICH (DFS)

Open the KICH breakdown →