DMC1

Across TCGA cell cohorts, DMC1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMC1-associated genes across cancer lineages are C8A and PRR27. Each is linked with DMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMC1-to-partner and partner-to-DMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8A grouped by DMC1-low versus DMC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMC1→partner) and Y-score (partner→DMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C8A →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	PRR27 →	+0.197	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

C8A by DMC1 expression — LARGE_INTESTINE

Explore this box plot interactively →