DMBT1L1

Across TCGA patient cohorts, DMBT1L1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMBT1L1-associated genes across cancer lineages are Chk2_pT68, 14-3-3_beta, and EGFR_pY1068. Each is linked with DMBT1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMBT1L1-to-partner and partner-to-DMBT1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by DMBT1L1-low versus DMBT1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMBT1L1→partner) and Y-score (partner→DMBT1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.151	-2.433	.043	.018	3	2
UCEC	14-3-3_beta →	-0.122	-3.432	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.227	-2.459	.024	.019	3	1
UCEC	A-Raf_pS299 →	-0.178	-2.115	<.001	.017	3	1
UCEC	ERK2 →	+0.209	+3.087	.006	<.001	3	1
UCEC	JNK2 →	+0.331	+2.348	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Chk2_pT68 by DMBT1L1 expression — UCEC

Explore this box plot interactively →