DM1-AS

Across TCGA pan-cancer cohorts, DM1-AS RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DM1-AS data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DM1-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DM1-AS expression acts as an unfavorable survival marker, although some lineages such as BLCA and THYM show a favorable association.

UCEC, ACC, and KIRC are the cancer types where DM1-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.785	0.887	<.001	88	view →
ACC	DFS	Median	All	0.229	0.646	<.001	71	view →
KIRC	DFS	Quartile	II,III,IV	0.648	0.817	.002	68	view →
BLCA	OS	Tertile	All	0.804	0.642	.003	63	view →
LGG	DFS	Median	All	0.651	0.815	<.001	48	view →
THYM	DFS	Median	II,III,IV	0.952	0.738	<.001	44	view →
PAAD	OS	Median	All	0.527	0.263	<.001	37	view →
STAD	DFS	Median	III,IV	0.184	0.579	.001	26	view →
COAD	OS	Median	All	0.814	0.917	.006	23	view →
PRAD	DFS	Median	All	0.652	0.909	<.001	18	view →
ESCA	DFS	Median	All	0.258	0.395	.037	17	view →
CHOL	DFS	Median	All	0.195	0.656	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DM1-AS–UCEC (DFS)

Open the UCEC breakdown →