DM1-AS

Across TCGA pan-cancer cohorts, DM1-AS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DM1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DM1-AS RNA is repressed in tumor relative to normal tissue. In most cancer types DM1-AS is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where DM1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DM1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.034	<.001	10	view →
KIRC	Male	All	−0.660	<.001	10	view →
KICH	Female	All	−1.480	<.001	8	view →
LIHC	Female	II,III,IV	+0.569	<.001	8	view →
KIRP	Male	All	−0.790	<.001	7	view →
CHOL	All	II,III,IV	+0.715	.012	3	view →
PAAD	All	All	+0.802	.005	2	view →
PRAD	All	All	+0.391	<.001	2	view →
COAD	Male	II,III,IV	+0.368	.004	2	view →
STAD	Male	IV	−0.905	.027	1	view →
BLCA	Male	IV	−0.787	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DM1-AS–THCA

Open the THCA breakdown →