DLX6-AS1

Across TCGA pan-cancer cohorts, DLX6-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DLX6-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher DLX6-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DLX6-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and LUSC show a favorable association.

UVM, ACC, and ESCA are the cancer types where DLX6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.247	0.711	<.001	77	view →
ACC	DFS	Median	All	0.416	0.744	<.001	57	view →
ESCA	DFS	Quartile	All	0.363	0.600	.004	49	view →
KIRP	OS	Median	All	0.455	0.774	.002	41	view →
READ	OS	Tertile	All	0.853	0.439	.003	30	view →
LUSC	DFS	Tertile	All	0.737	0.593	.001	27	view →
CHOL	DFS	Tertile	II,III,IV	0.167	0.476	.005	25	view →
MESO	DFS	Tertile	All	0.316	0.505	.019	15	view →
STAD	DFS	Quartile	All	0.346	0.607	.016	14	view →
THCA	DFS	Tertile	IV	0.968	0.600	.004	14	view →
LAML	DFS	Median	All	0.697	0.434	.005	12	view →
BRCA	DFS	Quartile	All	0.709	0.525	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DLX6-AS1–UVM (DFS)

Open the UVM breakdown →