DLX6-AS1

Across TCGA pan-cancer cohorts, DLX6-AS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DLX6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DLX6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DLX6-AS1 is over-expressed in tumor, although a few such as ESCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where DLX6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLX6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.925	<.001	11	view →
KIRC	Female	All	+0.083	<.001	8	view →
LUSC	Male	All	+1.048	<.001	7	view →
UCEC	All	II,III,IV	+2.820	<.001	6	view →
READ	All	III,IV	+0.924	.011	6	view →
BLCA	Female	All	+0.815	.002	6	view →
COAD	All	All	+0.216	.001	6	view →
LIHC	All	II,III,IV	+0.157	.012	3	view →
PRAD	All	All	+0.432	<.001	2	view →
CHOL	Male	All	+0.339	.027	2	view →
LUAD	Female	All	+0.291	<.001	2	view →
STAD	Male	All	+0.089	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DLX6-AS1–HNSC

Open the HNSC breakdown →