DLX4

Across TCGA patient cohorts, DLX4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX4-associated genes across cancer lineages are JNK2, Myosin-IIa, and Tuberin. Each is linked with DLX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX4-to-partner and partner-to-DLX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DLX4-low versus DLX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX4→partner) and Y-score (partner→DLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.249	+3.321	.017	.010	3	1
UCEC	Myosin-IIa →	+0.203	+2.177	.036	.035	3	1
UCEC	Tuberin →	+0.497	+2.999	<.001	.035	3	1
UCEC	BRD4 →	+0.346	+2.818	.013	.035	3	1
UCEC	4E-BP1 →	+0.404	+3.321	.004	.010	3	1
UCEC	p62 Lck ligand →	+0.543	+3.009	.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by DLX4 expression — UCEC

Explore this box plot interactively →