DLX4

Across TCGA pan-cancer cohorts, DLX4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DLX4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DLX4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DLX4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where DLX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+0.681	<.001	12	view →
COAD	Female	II,III,IV	+0.765	<.001	10	view →
HNSC	All	All	+0.749	<.001	10	view →
KIRP	Male	II,III,IV	+1.058	<.001	9	view →
THCA	Female	All	+0.410	<.001	7	view →
UCEC	All	II,III,IV	+1.402	<.001	6	view →
BRCA	All	II,III,IV	+0.549	<.001	6	view →
LIHC	All	All	+0.176	.001	6	view →
CHOL	All	All	+1.806	<.001	5	view →
LUSC	Male	II,III,IV	+1.060	<.001	5	view →
BLCA	All	All	+0.763	.004	5	view →
STAD	All	II,III,IV	+0.649	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DLX4–KIRC

Open the KIRC breakdown →