DLL4

Across TCGA patient cohorts, DLL4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLL4-associated genes across cancer lineages are GAPDH, MSH2, and 4E-BP1. Each is linked with DLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL4-to-partner and partner-to-DLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DLL4-low versus DLL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL4→partner) and Y-score (partner→DLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.484	+1.874	.021	.049	3	2
UCEC	MSH2 →	-0.238	-3.143	.008	.018	3	2
UCEC	4E-BP1 →	+0.283	+1.614	.007	.041	3	2
UCEC	14-3-3_beta →	-0.116	-1.571	.003	.036	3	1
UCEC	ERK2 →	+0.187	+1.584	.013	.036	3	1
UCEC	Heregulin →	-0.121	-2.000	.012	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GAPDH by DLL4 expression — UCEC

Explore this box plot interactively →