DLL4

Across TCGA cell cohorts, DLL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,497 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DLL4-associated GO terms across cancer lineages are Ventral spinal cord interneuron differentiation, Ventral spinal cord interneuron fate commitment, and Cell fate commitment involved in pattern specification. Each is linked with DLL4 in more than 14 cancer types. Because this analysis shows association rather than direction, both DLL4-to-partner and partner-to-DLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ventral spinal cord interneuron differentiation grouped by DLL4-low versus DLL4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL4→partner) and Y-score (partner→DLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Ventral spinal cord interneuron differentiation →	+1.425	+2.185	<.001	<.001	3	15
LUNG_SCLC	Ventral spinal cord interneuron fate commitment →	+1.425	+2.185	<.001	<.001	3	15
LUNG_SCLC	Cell fate commitment involved in pattern specification →	+1.425	+2.185	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of neural retina development →	+1.081	+1.540	.002	<.001	3	12
LIVER	Negative regulation of epithelial to mesenchymal transition →	+0.120	+0.986	.002	.006	3	7
LUNG_SCLC	Negative regulation of actin nucleation →	+0.213	+2.522	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

Ventral spinal cord interneuron differentiation by DLL4 expression — LUNG_SCLC

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