DLL4

Across TCGA cell cohorts, DLL4 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DLL4-associated genes across cancer lineages are GPR149, OR11H6, and DEFB108B. Each is linked with DLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL4-to-partner and partner-to-DLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR149 grouped by DLL4-low versus DLL4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL4→partner) and Y-score (partner→DLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPR149 →	+0.024	+4.321	<.001	.009	3	1
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	DEFB108B →	+0.040	+4.754	<.001	.005	3	1
BLOOD_Leukemia	SPEF1 →	+0.239	+3.595	<.001	.002	3	1
BLOOD_Leukemia	SLC32A1 →	+0.622	+2.638	<.001	.009	3	1
BLOOD_Leukemia	PHOX2B →	+0.020	+3.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

GPR149 by DLL4 expression — CNS

Explore this box plot interactively →