DLK2

Across TCGA patient cohorts, DLK2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLK2-associated genes across cancer lineages are eIF4E, Fibronectin, and p62 Lck ligand. Each is linked with DLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLK2-to-partner and partner-to-DLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DLK2-low versus DLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLK2→partner) and Y-score (partner→DLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+2.820	.038	.035	3	1
UCEC	Fibronectin →	-0.349	-2.986	.023	.035	3	1
UCEC	p62 Lck ligand →	+0.389	+3.179	.010	.010	3	1
UCEC	PCNA →	+0.313	+3.169	.001	.018	3	1
UCEC	PRDX1 →	+0.250	+3.321	.009	.010	3	1
UCEC	Annexin-1 →	+0.561	+3.019	.022	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by DLK2 expression — UCEC

Explore this box plot interactively →