DLGAP4

Across TCGA pan-cancer cohorts, DLGAP4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DLGAP4 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DLGAP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DLGAP4 expression acts as an unfavorable survival marker, although some lineages such as UCS and PAAD show a favorable association.

MESO, KICH, and LIHC are the cancer types where DLGAP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.267	0.464	<.001	108	view →
KICH	DFS	Tertile	III,IV	0.033	1.000	.004	81	view →
LIHC	DFS	Median	All	0.450	0.630	<.001	78	view →
UCS	DFS	Median	III,IV	0.466	0.119	<.001	46	view →
BLCA	DFS	Median	All	0.168	0.527	<.001	30	view →
LUSC	DFS	Median	III,IV	0.215	0.536	<.001	30	view →
UCEC	DFS	Tertile	All	0.571	0.721	<.001	22	view →
LGG	OS	Quartile	All	0.810	0.934	.001	17	view →
PAAD	OS	Tertile	All	0.546	0.219	.012	16	view →
ACC	DFS	Quartile	All	0.265	0.624	.013	14	view →
CHOL	DFS	Quartile	All	0.701	0.257	.041	6	view →
UVM	DFS	Median	All	0.565	0.858	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DLGAP4–MESO (DFS)

Open the MESO breakdown →