DLGAP4

Across TCGA pan-cancer cohorts, DLGAP4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DLGAP4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DLGAP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DLGAP4 is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where DLGAP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLGAP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.306	<.001	12	view →
KIRP	All	II,III,IV	+0.993	<.001	11	view →
KIRC	Female	All	+0.887	<.001	11	view →
COAD	Male	II,III,IV	+0.994	<.001	10	view →
LIHC	Female	II,III,IV	+1.627	<.001	9	view →
THCA	Male	All	+0.685	<.001	9	view →
STAD	All	II,III,IV	+0.905	<.001	7	view →
READ	All	III,IV	+1.229	.002	6	view →
BRCA	All	III,IV	+0.399	<.001	6	view →
LUAD	All	II,III,IV	+0.467	.001	5	view →
LUSC	All	All	+0.369	<.001	4	view →
CHOL	Male	All	+2.956	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DLGAP4–HNSC

Open the HNSC breakdown →