DLGAP3

Across TCGA cell cohorts, DLGAP3 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLGAP3-associated genes across cancer lineages are HTR5A, OR56B1, and CRYBA1. Each is linked with DLGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLGAP3-to-partner and partner-to-DLGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR5A grouped by DLGAP3-low versus DLGAP3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLGAP3→partner) and Y-score (partner→DLGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR5A →	+0.365	+3.196	.001	.007	3	2
LUNG_NSCLC_LUAD	OR56B1 →	+0.021	+3.472	.004	.004	3	2
LUNG_NSCLC_LUAD	CRYBA1 →	+0.101	+4.121	<.001	<.001	3	1
LUNG_NSCLC_LUAD	LAX1 →	+0.031	+3.370	.007	.008	3	1
LUNG_NSCLC_LUAD	OR3A1 →	+0.470	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.208	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

HTR5A by DLGAP3 expression — SKIN

Explore this box plot interactively →