DLG5

Across TCGA pan-cancer cohorts, DLG5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DLG5 data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DLG5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DLG5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where DLG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.917	0.745	.001	57	view →
CCRCC	OS	Quartile	All	0.546	1.000	.002	40	view →
LUAD	DFS	Tertile	II,III,IV	0.204	1.000	.002	18	view →
PDAC	OS	Median	III,IV	0.304	0.603	.009	17	view →
UCEC	DFS	Tertile	All	0.969	0.816	.008	10	view →
LSCC	DFS	Tertile	II,III,IV	0.415	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DLG5–HNSC (OS)

Open the HNSC breakdown →