DLG4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DLG4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,987 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DLG4-associated genes across cancer lineages are SH3GL2, IGSF21, and NACAD. Each is linked with DLG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLG4-to-partner and partner-to-DLG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DLG4 versus SH3GL2 in GBM, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG4→partner) and Y-score (partner→DLG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSH3GL2 →+1.454+0.618<.001<.00132
GBMIGSF21 →+1.043+0.550<.001<.00132
GBMNACAD →+0.884+0.682<.001<.00132
GBMPRDM8 →+0.893+0.737<.001<.00132
LSCCCATSPER1 →+0.292+0.466.005<.00132
GBMWSCD2 →+1.123+0.748<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,987 associations by consensus.

DLG4 vs SH3GL2 — GBM

Per-sample scatter of DLG4 vs SH3GL2 in GBM (Pearson r = 0.55).

Explore this scatter interactively →

Exploration