DLG4

Across TCGA patient cohorts, DLG4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG4-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and PDCD4. Each is linked with DLG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLG4-to-partner and partner-to-DLG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DLG4-low versus DLG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG4→partner) and Y-score (partner→DLG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.213	+1.947	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.114	-1.787	.012	.003	3	2
UCEC	PDCD4 →	-0.450	-2.222	.001	.009	3	2
UCEC	ASNS →	+0.398	+1.765	<.001	.011	3	2
UCEC	Caspase-8 →	-0.194	-2.060	.011	.004	3	2
COAD	MIG-6 →	+0.115	+3.229	.017	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by DLG4 expression — UCEC

Explore this box plot interactively →