DLG4

Across TCGA cell cohorts, DLG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,131 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DLG4-associated GO terms across cancer lineages are AMPA glutamate receptor clustering, Glutamate receptor clustering, and Regulation of telomere capping. Each is linked with DLG4 in more than 16 cancer types. Because this analysis shows association rather than direction, both DLG4-to-partner and partner-to-DLG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPA glutamate receptor clustering grouped by DLG4-low versus DLG4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG4→partner) and Y-score (partner→DLG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AMPA glutamate receptor clustering →	+1.346	+2.864	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Glutamate receptor clustering →	+1.346	+2.864	<.001	<.001	3	17
KIDNEY	Regulation of telomere capping →	+0.080	+1.460	<.001	<.001	3	14
OESOPHAGUS	Locomotory exploration behavior →	+0.295	+2.021	<.001	<.001	3	14
STOMACH	Calcium-independent cell-matrix adhesion →	+0.219	+1.832	<.001	<.001	3	14
LARGE_INTESTINE	Thigmotaxis →	+0.300	+0.710	.005	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,131 associations by consensus.

AMPA glutamate receptor clustering by DLG4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →