DLG2-AS2

Across TCGA pan-cancer cohorts, DLG2-AS2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DLG2-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DLG2-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types DLG2-AS2 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and KIRC are the cancer types where DLG2-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLG2-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.470	<.001	11	view →
KIRP	Male	All	−0.032	<.001	6	view →
KIRC	All	II,III,IV	−0.014	.001	5	view →
HNSC	All	II,III,IV	−0.025	.002	4	view →
BLCA	Male	All	−0.068	.024	2	view →
LUSC	Female	All	−0.034	.020	2	view →
ESCA	Female	All	−0.056	.013	1	view →
STAD	All	All	−0.048	.042	1	view →
KICH	All	All	−0.026	.029	1	view →
LIHC	Female	III,IV	+0.022	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DLG2-AS2–THCA

Open the THCA breakdown →