DLG1

Across TCGA patient cohorts, DLG1 mutation is significantly associated with the RNA expression of many other genes, with 4,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG1-associated genes across cancer lineages are MMP12, RN7SL134P, and MIR541. Each is linked with DLG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLG1-to-partner and partner-to-DLG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP12 grouped by DLG1-low versus DLG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG1→partner) and Y-score (partner→DLG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MMP12 →	+1.173	+2.243	<.001	.005	3	2
UCEC	RN7SL134P →	+0.093	+2.014	.002	.003	3	2
BLCA	MIR541 →	+0.555	+4.296	<.001	.006	3	2
HNSC	RPL21P92 →	+0.175	+3.869	<.001	.008	3	2
HNSC	HMGN1P20 →	+0.131	+3.780	.001	.007	3	2
HNSC	H3P40 →	+0.103	+4.141	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,372 associations by consensus.

MMP12 by DLG1 expression — UCEC

Explore this box plot interactively →