DLEC1

Across TCGA patient cohorts, DLEC1 mutation is significantly associated with the RNA expression of many other genes, with 5,495 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLEC1-associated genes across cancer lineages are CENPO, NDOR1, and PRMT5. Each is linked with DLEC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DLEC1-to-partner and partner-to-DLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPO grouped by DLEC1-low versus DLEC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLEC1→partner) and Y-score (partner→DLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPO →	+0.553	+1.642	<.001	<.001	3	4
UCEC	NDOR1 →	+0.497	+2.115	<.001	<.001	3	4
UCEC	PRMT5 →	+0.546	+1.478	<.001	<.001	3	3
SKCM	EIF2B4 →	+0.228	+2.151	.001	.002	3	3
UCEC	OPA3 →	+0.283	+1.675	<.001	<.001	3	3
COAD	ERP27 →	-1.153	-3.584	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,495 associations by consensus.

CENPO by DLEC1 expression — UCEC

Explore this box plot interactively →