DLEC1

Across TCGA pan-cancer cohorts, DLEC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DLEC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DLEC1 RNA is repressed in tumor relative to normal tissue. In most cancer types DLEC1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where DLEC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLEC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.205	<.001	12	view →
KICH	Male	All	−0.475	<.001	11	view →
LUAD	All	II,III,IV	−1.008	<.001	9	view →
LUSC	Male	II,III,IV	−1.546	<.001	7	view →
BRCA	All	III,IV	−0.625	<.001	6	view →
COAD	Female	All	−0.248	.005	5	view →
THCA	Female	All	+0.472	<.001	3	view →
LIHC	Male	III,IV	−0.142	.008	3	view →
HNSC	Male	IV	+0.687	.027	2	view →
PRAD	All	All	−0.246	<.001	2	view →
STAD	All	II,III,IV	+0.126	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DLEC1–KIRC

Open the KIRC breakdown →