DLEC1

Across TCGA patient cohorts, DLEC1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLEC1-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and FASN. Each is linked with DLEC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DLEC1-to-partner and partner-to-DLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DLEC1-low versus DLEC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLEC1→partner) and Y-score (partner→DLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.024	+2.467	.002	.011	3	5
UCEC	ATM →	-0.443	-1.540	<.001	.001	3	3
COAD	FASN →	+0.607	+3.593	<.001	.001	3	3
LUSC	Cyclin-B1 →	+0.821	+2.816	<.001	.036	2	3
SKCM	IRS1 →	+0.145	+1.602	.005	.038	3	2
SKCM	LKB1 →	+0.084	+1.523	.033	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by DLEC1 expression — COAD

Explore this box plot interactively →