DLEC1

Across TCGA cell cohorts, DLEC1 mutation is significantly associated with the RNA expression of many other genes, with 347 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLEC1-associated genes across cancer lineages are NAA38, G6PC2, and TIMM50. Each is linked with DLEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLEC1-to-partner and partner-to-DLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA38 grouped by DLEC1-low versus DLEC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLEC1→partner) and Y-score (partner→DLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA38 →	+1.269	+3.628	<.001	<.001	3	2
STOMACH	G6PC2 →	+0.062	+3.857	<.001	.004	3	2
LARGE_INTESTINE	TIMM50 →	+0.379	+2.502	.009	.005	3	2
LARGE_INTESTINE	NDUFAF4 →	+0.562	+3.628	.003	<.001	3	2
LARGE_INTESTINE	THNSL1 →	+0.728	+3.087	<.001	.006	3	2
PANCREAS	GZMH →	+0.056	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 347 associations by consensus.

NAA38 by DLEC1 expression — LARGE_INTESTINE

Explore this box plot interactively →