DLD

Across TCGA pan-cancer cohorts, DLD Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DLD data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher DLD Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DLD expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, LIHC, and LAML are the cancer types where DLD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.153	0.781	<.001	30	view →
LIHC	DFS	Median	II,III,IV	0.079	0.429	<.001	18	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.623	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DLD–SKCM (OS)

Open the SKCM breakdown →