DLD

Across TCGA pan-cancer cohorts, DLD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DLD data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DLD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DLD expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where DLD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	78	view →
PDAC	DFS	Tertile	All	0.423	0.209	.010	11	view →
LUAD	DFS	Quartile	All	0.440	0.780	.017	6	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.774	.025	5	view →
CCRCC	OS	Median	All	0.984	0.907	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DLD–COAD (DFS)

Open the COAD breakdown →