DKKL1

Across TCGA patient cohorts, DKKL1 protein abundance is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DKKL1-associated genes across cancer lineages are CHKB, SGSM3, and EP300. Each is linked with DKKL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKKL1-to-partner and partner-to-DKKL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKKL1 versus CHKB in GBM, with a Pearson correlation of 0.92.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKKL1→partner) and Y-score (partner→DKKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHKB →	+0.559	+0.494	.004	.005	3	1
GBM	SGSM3 →	+0.519	+0.494	.003	.005	3	1
GBM	EP300 →	+1.519	+0.770	<.001	<.001	3	1
GBM	OGG1 →	+0.712	+0.494	.004	.005	3	1
GBM	FOXO3 →	+1.146	+0.770	.001	<.001	3	1
GBM	SOHLH2 →	-0.730	-0.658	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

DKKL1 vs CHKB — GBM

Explore this scatter interactively →