DKKL1

Across TCGA cell cohorts, DKKL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,628 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DKKL1-associated GO terms across cancer lineages are Negative regulation of testosterone biosynthetic process, Histamine uptake, and Renal vesicle formation. Each is linked with DKKL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both DKKL1-to-partner and partner-to-DKKL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of testosterone biosynthetic process grouped by DKKL1-low versus DKKL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DKKL1→partner) and Y-score (partner→DKKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of testosterone biosynthetic process →	-0.286	-1.141	<.001	<.001	3	10
BONE	Histamine uptake →	+1.393	+0.835	<.001	<.001	3	8
OVARY	Renal vesicle formation →	+1.300	+0.922	<.001	<.001	3	8
OVARY	Metanephric renal vesicle formation →	+1.300	+0.922	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Heart contraction →	-0.148	-0.336	.001	.002	3	8
BONE	Locomotory exploration behavior →	+0.232	+1.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,628 associations by consensus.

Negative regulation of testosterone biosynthetic process by DKKL1 expression — BONE

Explore this box plot interactively →