DKC1

Across TCGA patient cohorts, DKC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,619 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DKC1-associated proteins across cancer lineages are WDR12, NKRF, and POLR1E. Each is linked with DKC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both DKC1-to-partner and partner-to-DKC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKC1 versus WDR12 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DKC1→partner) and Y-score (partner→DKC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR12 →	+0.516	+0.785	<.001	<.001	3	10
LSCC	NKRF →	+0.592	+0.900	<.001	<.001	3	10
BRCA	POLR1E →	+0.454	+0.519	<.001	<.001	3	9
UCEC	SMC2 →	+0.717	+0.820	<.001	<.001	3	9
LSCC	THOC1 →	+0.297	+0.821	<.001	<.001	3	9
GBM	THOC2 →	+0.329	+0.377	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,619 associations by consensus.

DKC1 vs WDR12 — LSCC

Explore this scatter interactively →