Across TCGA cell cohorts, DISP3 mutation is significantly associated with the RNA expression of many other genes, with 1,323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DISP3-associated genes across cancer lineages are THAP3, TTC8, and OR4E1. Each is linked with DISP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DISP3-to-partner and partner-to-DISP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP3→partner) and Y-score (partner→DISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	THAP3 →	+0.633	+3.459	<.001	<.001	3	3
LUNG_SCLC	TTC8 →	+0.654	+3.334	.005	.006	3	2
LUNG_SCLC	OR4E1 →	+0.006	+2.616	<.001	.005	3	2
BLOOD_Leukemia	CST2 →	+0.496	+4.152	<.001	.009	3	2
BREAST	BANF2 →	+0.266	+4.087	<.001	<.001	3	2
BREAST	OR11H2 →	+0.023	+3.727	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,323 associations by consensus.

Exploration

DISP3 survival (RNA) · tumor vs normal (RNA) · all DISP3 data types