DISP2

Across TCGA cell cohorts, DISP2 mutation is significantly associated with the RNA expression of many other genes, with 567 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DISP2-associated genes across cancer lineages are CLDN8, SCD5, and KIFC1. Each is linked with DISP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DISP2-to-partner and partner-to-DISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN8 grouped by DISP2-low versus DISP2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP2→partner) and Y-score (partner→DISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLDN8 →	+0.015	+4.930	<.001	.008	3	2
BLOOD_Leukemia	SCD5 →	+1.725	+3.199	.002	.007	3	2
BLOOD_Leukemia	KIFC1 →	+0.723	+3.199	.009	.007	3	2
BLOOD_Leukemia	MCM6 →	+0.562	+3.199	.009	.007	3	2
BLOOD_Leukemia	MPND →	+0.714	+3.199	.007	.007	3	2
BLOOD_Leukemia	SEPHS1 →	+0.936	+3.199	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 567 associations by consensus.

CLDN8 by DISP2 expression — SOFT_TISSUE

Explore this box plot interactively →