DIS3L

Across TCGA pan-cancer cohorts, DIS3L Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DIS3L data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher DIS3L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DIS3L expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

OV, HNSC, and BLCA are the cancer types where DIS3L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	III,IV	0.028	0.837	<.001	24	view →
HNSC	DFS	Median	IV	0.163	0.672	.002	24	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
UCEC	DFS	Median	All	0.963	0.609	.006	10	view →
SKCM	DFS	Median	II,III,IV	1.000	0.683	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DIS3L–OV (OS)

Open the OV breakdown →