DIS3L

Across TCGA pan-cancer cohorts, DIS3L mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DIS3L data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DIS3L mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DIS3L expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where DIS3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.581	<.001	22	view →
PDAC	DFS	Quartile	III,IV	0.163	0.854	.002	18	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	12	view →
LUAD	DFS	Tertile	II,III,IV	0.271	0.871	.018	7	view →
HNSC	OS	Tertile	III,IV	0.347	1.000	.027	4	view →
GBM	OS	Median	All	0.461	0.280	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DIS3L–CCRCC (OS)

Open the CCRCC breakdown →