DIRC3-AS1

Across TCGA pan-cancer cohorts, DIRC3-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated DIRC3-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher DIRC3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DIRC3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

LGG, UCEC, and BLCA are the cancer types where DIRC3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.670	0.801	<.001	51	view →
UCEC	DFS	Tertile	All	0.570	0.676	.005	48	view →
BLCA	OS	Quartile	II,III,IV	0.553	0.371	.005	43	view →
LAML	DFS	Tertile	All	0.247	0.526	.002	40	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	28	view →
READ	DFS	Tertile	II,III,IV	0.381	0.834	.003	21	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
KIRC	DFS	Quartile	IV	0.204	0.561	.006	18	view →
LUSC	DFS	Tertile	II,III,IV	0.644	0.773	.008	14	view →
LUAD	DFS	Quartile	IV	0.412	0.891	.004	14	view →
CHOL	DFS	Tertile	III,IV	0.133	0.779	.038	12	view →
SARC	OS	Quartile	All	0.464	0.798	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DIRC3-AS1–LGG (DFS)

Open the LGG breakdown →