DIRC3-AS1

Across TCGA pan-cancer cohorts, DIRC3-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DIRC3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DIRC3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types DIRC3-AS1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where DIRC3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIRC3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.317	<.001	7	view →
COAD	Male	II,III,IV	−0.142	.005	7	view →
KIRC	All	III,IV	+0.083	.025	5	view →
BRCA	All	All	−0.118	.008	4	view →
KIRP	Male	All	−0.091	.002	3	view →
BLCA	Male	All	−0.686	.043	2	view →
CHOL	All	II,III,IV	+0.600	.043	2	view →
READ	All	All	−0.130	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DIRC3-AS1–THCA

Open the THCA breakdown →