DIRAS3

Across TCGA patient cohorts, DIRAS3 mutation is significantly associated with the RNA expression of many other genes, with 3,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIRAS3-associated genes across cancer lineages are MIR8069-2, ANXA2P3, and MIR7-3. Each is linked with DIRAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS3-to-partner and partner-to-DIRAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8069-2 grouped by DIRAS3-low versus DIRAS3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS3→partner) and Y-score (partner→DIRAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR8069-2 →	+0.313	+7.640	<.001	.009	3	2
UCEC	ANXA2P3 →	+0.349	+2.815	<.001	.002	3	2
CESC	MIR7-3 →	+0.370	+6.342	<.001	.001	3	2
LUAD	AQP7P4 →	+0.035	+4.984	<.001	.005	3	2
LUAD	CAPZA1P3 →	+0.072	+4.293	.006	.008	3	2
LUAD	RNU6-791P →	+0.282	+5.912	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,616 associations by consensus.

MIR8069-2 by DIRAS3 expression — BLCA

Explore this box plot interactively →