DIRAS3

Across TCGA pan-cancer cohorts, DIRAS3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DIRAS3 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DIRAS3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DIRAS3 expression acts as an unfavorable survival marker, although some lineages such as KIRP and THCA show a favorable association.

KIRP, THCA, and BRCA are the cancer types where DIRAS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.875	0.281	<.001	116	view →
THCA	DFS	Tertile	All	0.890	0.754	.002	80	view →
BRCA	OS	Tertile	All	0.954	0.900	.002	66	view →
BLCA	OS	Quartile	All	0.516	0.697	.002	54	view →
LGG	DFS	Median	All	0.630	0.845	<.001	54	view →
SCLC	OS	Tertile	III,IV	0.827	0.295	<.001	44	view →
ESCA	OS	Median	IV	0.222	0.698	.006	30	view →
GBM	DFS	Tertile	All	0.150	0.433	<.001	20	view →
SKCM	OS	Quartile	All	0.826	0.687	.012	19	view →
COAD	DFS	Median	All	0.451	0.674	.007	19	view →
OV	DFS	Median	All	0.414	0.347	.026	18	view →
UVM	OS	Median	III,IV	0.304	1.000	.008	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DIRAS3–KIRP (OS)

Open the KIRP breakdown →